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20 September 2020

Association Between Fat Mass in Early Life and Later Fat Mass Trajectories

Posted in Scientific

American Journal of Respiratory and Critical Care Medicine

In this study, only the change in FM% in the first 6 months of life was associated with more adiposity at age 2 years. Infants with a rapid increase in FM% had higher trajectories of FM% and FM index during the first 2 years of life. These findings appear to support a critical window for adiposity programming in early life.

Question  
Is a rapid increase in fat mass percentage in early life associated with higher trajectories of body fat mass during the first 2 years of life?

Findings  
In a cohort study of 401 infants, only the change in fat mass percentage during the first 6 months of life was associated with fat mass percentage and abdominal subcutaneous fat mass at age 2 years. A rapid increase in fat mass percentage during that period was associated with higher trajectories of body fat mass during the first 2 years of life.

Meaning  
The data from this study suggest that the first 6 months of life are a critical window for adiposity programming, which may have major implications for primary health care.


Article details:

- Title: Association Between Fat Mass in Early Life and Later Fat Mass Trajectories
- Authors: Kirsten S. de Fluiter, MD; Inge A. L. P. van Beijsterveldt, MD; Laura M. Breij, MD, PhD; Dennis Acton, PhD; Anita C. S. Hokken-Koelega, MD, PhD
- Published in: JAMA Pediatrics 174(12)
- Link: https://doi.org/10.1001/jamapediatrics.2020.2673